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December 8, 2025BloodOpen Access

Distinct roles of fetal hematopoietic stem and progenitor cells in building the immune system

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Authors

SHShinya HatanoPPPablo Pereira

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Overview

Experimental models reveal hematopoietic stem cells contribute minimally to blood cells before birth, implying embryonic progenitors drive fetal immune system formation.

Key Points

  • To investigate the distinct roles of fetal hematopoietic stem and progenitor cells in immune system development.
  • Utilized lineage-tracing models to analyze fetal hematopoiesis.
  • Examined temporal changes in contributions of hematopoietic stem cells and multipotent progenitors in late gestation.
  • Assessed differentiation and generation of immune cells from each progenitor type.
  • Hematopoietic stem cells contributed minimally to blood cells before birth.
  • Embryonic multipotent progenitors were identified as primary drivers of hematopoiesis during late gestation.
  • Findings support a model stating embryonic progenitors are the main source of immune cells in fetal life.

Cite This Study

Hatano et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d07bhttps://doi.org/10.1182/blood-2025-3150
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Also Consider

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  1. 1Clonal analysis of fetal hematopoietic stem/progenitor cells reveals how post-transplantation capabilities are distributed2024 · 4 citations
  2. 2Fetal-restricted hematopoietic progenitors arise from hemogenic endothelium in vitelline and umbilical arteries2026 · 1 citations
  3. 3Clonal analysis of fetal hematopoietic stem/progenitor cell subsets reveals how post-transplantation capabilities are distributed2024 · 3 citations
  4. 4Hemogenic endothelium of the vitelline and umbilical arteries is the major contributor to mouse fetal lympho-myelopoiesis2024 · 2 citations
  5. 5Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth2024 · 7 citations