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December 8, 2025BloodOpen Access

Aplastic anemia treatment in older adults in resource-limited settings: Can rabbit ATG bridge the gap?

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Authors

DCDavid Solar CafaggiYGY GarcíaLJLeire Montoya Jiménez

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Overview

Multicenter study reveals lower overall response rates in elderly patients with aplastic anemia treated with rabbit ATG compared to standard therapies, indicating a need for treatment reassessment.

Key Points

  • The aim was to determine if rabbit ATG improves overall response rates in elderly patients with severe aplastic anemia.
  • Conducted a multicenter study in five referral centers in Mexico.
  • Defined treatment groups: rabbit ATG plus immunosuppressive therapy, standard therapy with CsA/ETB, and other treatments.
  • Assessed overall response at 3, 6, and 12 months after treatment initiation.
  • Patients treated with CsA/ETB consistently showed higher overall response rates at all time points across the study.
  • Overall response was significantly lower in rabbit ATG group compared to CsA/ETB.
  • Median overall survival was longest in CsA/ETB group, suggesting better efficacy.

Cite This Study

Cafaggi et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d089https://doi.org/10.1182/blood-2025-1095
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