What question did this study set out to answer?

To investigate the impact of measurable residual disease on survival outcomes in multiple myeloma patients.

December 8, 2025Blood

Measurable residual disease in newly diagnosed multiple myeloma: Experience from a large cohort from an academic medical center

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Authors

AAAndrés ArroyoUniversidad Complutense de Madrid ACAjai ChariUniversity of California, San Francisco SAShagun AroraChildren's Hospital of Philadelphia

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Implication

Findings show improved progression-free survival and overall survival in multiple myeloma patients with MRD- status, indicating critical therapeutic strategies.

Key Points

To investigate the impact of measurable residual disease on survival outcomes in multiple myeloma patients.
Reviewed clinical records of 636 multiple myeloma patients at UCSF from November 2017 to May 2024.
Assessed MRD in bone marrow samples using clonoSEQ® assay to define negative MRD.
Analyzed baseline characteristics and treatment regimens, focusing on autologous stem cell transplantation outcomes.
42.3% of patients achieved MRD- status, correlating with improved progression-free survival and overall survival.
Hazard risk for progression-free survival was 0.45 and for overall survival was 0.5 for MRD- patients.
MRD status evaluated at 1 and 2 years post-transplantation showed predictive value for better outcomes.

Cite This Study

Arroyo et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d0c5 https://doi.org/10.1182/blood-2025-2234

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Implication

Findings show improved progression-free survival and overall survival in multiple myeloma patients with MRD- status, indicating critical therapeutic strategies.

Measurable residual disease in newly diagnosed multiple myeloma: Experience from a large cohort from an academic medical center

Discussion

Member takes

Implication

Key Points

Cite This Study

Measurable residual disease in newly diagnosed multiple myeloma: Experience from a large cohort from an academic medical center

Discussion

Member takes

Implication

Key Points

Cite This Study

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