What question did this study set out to answer?

This research aims to explore how dietary serine restriction affects the efficacy of venetoclax in treating acute myeloid leukemia.

December 8, 2025BloodOpen Access

Dietary serine restriction increases venetoclax efficacy in Acute Myeloid Leukemia

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Experiments demonstrate that serine depletion increases cell death in AML, suggesting metabolic interventions may improve venetoclax effectiveness.

This research aims to explore how dietary serine restriction affects the efficacy of venetoclax in treating acute myeloid leukemia.
Investigated the effects of serine deprivation on AML cell proliferation in culture.
Used isotope tracing analysis with mass spectrometry to assess serine synthesis pathway flux.
Conducted in vivo experiments by xenografting NSG mice with AML cells and applying dietary interventions.
Serine depletion significantly reduced proliferation rates of various AML cell lines.
Combined treatment with serine-free diet and venetoclax increased cell death and early apoptosis.
In vivo, mice on a serine-free diet had delayed AML progression compared to those on a regular diet.

Michael J. Betenbaugh (2025) studied this question.

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December 8, 2025BloodOpen Access

View Full Paper

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Authors

Experiments demonstrate that serine depletion increases cell death in AML, suggesting metabolic interventions may improve venetoclax effectiveness.

This research aims to explore how dietary serine restriction affects the efficacy of venetoclax in treating acute myeloid leukemia.
Investigated the effects of serine deprivation on AML cell proliferation in culture.
Used isotope tracing analysis with mass spectrometry to assess serine synthesis pathway flux.
Conducted in vivo experiments by xenografting NSG mice with AML cells and applying dietary interventions.
Serine depletion significantly reduced proliferation rates of various AML cell lines.
Combined treatment with serine-free diet and venetoclax increased cell death and early apoptosis.
In vivo, mice on a serine-free diet had delayed AML progression compared to those on a regular diet.

Michael J. Betenbaugh (2025) studied this question.

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