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This analysis investigates characteristics and outcomes of hospitalizations due to post-transplant lymphoproliferative disorders (PTLD).

December 8, 2025BloodOpen Access

Characteristics, epidemiology and outcomes of post-transplant lymphoproliferative disorders associated hospitalizations: A 2016-2022 national inpatient sample analysis

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Analysis shows treatment outcomes and demographics of PTLD-related hospitalizations, indicating higher risk with certain comorbidities.

This analysis investigates characteristics and outcomes of hospitalizations due to post-transplant lymphoproliferative disorders (PTLD).
Analyzed National Inpatient Sample (2016-2022) data for PTLD hospitalizations using ICD-10 codes.
Used chi-squared and Wilcoxon rank sum tests for categorical and continuous variables comparisons.
Implemented multivariable logistic regression and Cox-Proportional Hazards models for outcome analysis.
4694 PTLD-associated hospitalizations from 2016-2022; 60% were male and median age was 52 years.
Majority of hospitalizations were after solid organ transplant, especially kidney transplant (43%).
Tumor lysis syndrome was found in 3.5% of cases, correlating with increased mortality and longer lengths of stay.

Kangning Peng (2025) studied this question.

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