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December 8, 2025BloodOpen Access

IL-17–Induced CD70 expression promotes T-cell suppression in DLBCL: Implications for immune escape and T-cell exhaustion

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Authors

DMDitipriya Mukherjee

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Overview

Findings demonstrate IL-17 induces CD70, enhancing T-cell suppression in DLBCL, suggesting new therapy targets.

Key Points

  • This research aims to elucidate the role of IL-17 and CD70 in T-cell suppression within DLBCL.
  • Utilized immunofluorescence and flow cytometric analysis to study T-cell and CD70 interactions.
  • Conducted high-throughput proteomics on IL-17-treated Raji B-cells.
  • Performed co-culture experiments with primary T-cells and IL-17-treated tumor cells to assess cytokine profiles.
  • Identified CD70 as significantly upregulated in response to IL-17 treatment in Raji cells.
  • Found a two-fold increase in CD70 expression in DLBCL patient samples compared to healthy controls.
  • Showed IL-17 treatment leads to increased regulatory T cells and diminished pro-inflammatory cytokine secretion.

Cite This Study

Ditipriya Mukherjee (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d15ahttps://doi.org/10.1182/blood-2025-5036
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lymphoma cell-driven IL-16 is expressed in activated B-cell-like diffuse large Bcell lymphomas and regulates the pro-tumor microenvironment2024 · 9 citations
  2. 2Abstract PR002: <i>Bcl6</i> -driven <i>Cd70</i> -deficient Diffuse large B-cell lymphomas originate from innate-like cells with blunted CD4+ cytotoxic T-cell immune surveillance2026
  3. 3IL‑10 limits CLL progression by reprogramming T cell exhaustion and myeloid suppression2025
  4. 4Tumor-derived HMGB2 induces M2-like macrophage polarization via TRIM65-mediated NLRP3 degradation to promote DLBCL progression2026
  5. 5Integrated multi-omics profiling reveals the ZZZ3/CD70 axis is a super-enhancer-driven regulator of diffuse large B-cell lymphoma cell-natural killer cell interactions2024