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December 8, 2025BloodOpen Access

The NLP protein is a novel regulator of G2-m Phase of the cell cycle critical for proliferation of human peripheral T-cell lymphomas

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Authors

JOJana OpavskaAIAlexander M. IshovRORené Opavský

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Overview

Functional screening uncovers NLP as a key regulator of malignant T-cell proliferation and apoptosis in PTCLs, suggesting novel therapeutic targets.

Key Points

  • To identify the role of NLP protein in regulating the G2-m phase of the cell cycle in peripheral T-cell lymphomas (PTCLs).
  • Used functional screening to identify NLP as a critical gene for PTCL cell survival.
  • Analyzed the localization and features of the NLP protein.
  • Conducted experiments on cancer cell lines to observe the effects of NLP loss.
  • NLP loss induced G2–M arrest and mitotic catastrophe, leading to apoptosis in malignant T-cells.
  • NLP is overexpressed in >95% of PTCL cases and associated with various solid tumors.
  • NLP depletion did not affect normal T-cells or other non-cancerous cell types.

Cite This Study

Opavska et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d15ehttps://doi.org/10.1182/blood-2025-5040
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