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December 8, 2025BloodOpen Access

Mixed autoimmune hemolytic anemia as a rare initial presentation of systemic lupus erythematosus

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Authors

MKMarina KhanEAEmeka Agudile

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Overview

Case report reveals mixed autoimmune hemolytic anemia in a young female, suggesting SLE as a possible cause.

Key Points

  • To report a rare case of mixed autoimmune hemolytic anemia as the initial manifestation of systemic lupus erythematosus.
  • Case report of a 22-year-old female with severe anemia and positive tests for SLE.
  • Treatment involved immunosuppressive therapy with prednisone and IVIG.
  • Lab tests included hemoglobin levels, Direct Coombs Test, and autoimmune panels.
  • Patient initially presented with a hemoglobin of 5.3 g/dL and required treatment for severe anemia.
  • Improved hemoglobin levels reached 7.6 g/dL post treatment with prednisone and IVIG.
  • SLE was confirmed based on positive double-stranded DNA and ANA tests.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1a5https://doi.org/10.1182/blood-2025-6438
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mixed Autoimmune Hemolytic Anemia - A Rare Case Report2024
  2. 2Mixed autoimmune hemolytic anemia as the initial presentation of systemic lupus erythematosus: A case report and review2024 · 3 citations
  3. 3Severe Warm Autoimmune Hemolytic Anemia With Profound Anemia Requiring Multimodal Immunosuppressive Therapy2026
  4. 4A Rare Presentation of Mixed Warm and Cold Autoimmune Hemolytic Anemia2026
  5. 5Red cell serological characterization of autoimmune hemolytic anemia in systemic lupus erythematosus patients2024