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December 8, 2025BloodOpen Access

Diagnostic delays and misdiagnosis patterns in paroxysmal nocturnal hemoglobinuria

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Authors

SPS.R. PierceKQKhaleel QuasemDIDaniel Isaac

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Overview

Systematic review reveals diagnostic delays in paroxysmal nocturnal hemoglobinuria, suggesting misidentification as common hematologic disorders.

Key Points

  • To identify and analyze patterns in diagnostic delays and misdiagnosis of paroxysmal nocturnal hemoglobinuria (PNH).
  • Systematic review conducted following PRISMA guidelines.
  • Search of PubMed, Embase, and Google Scholar for English-language reports on PNH with documented delays or misdiagnoses.
  • Extraction of data by independent reviewers on demographics, symptoms, initial misdiagnoses, and clinical outcomes.
  • Included 68 patients with median age at symptom onset of 30 years, younger than the international registry average.
  • Median diagnostic delay was 24 months, with only 20.6% diagnosed within one year.
  • Frequent initial misdiagnoses included iron-deficiency anemia and aplastic anemia, causing significant delays.

Cite This Study

Pierce et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1aehttps://doi.org/10.1182/blood-2025-6433
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