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To report a rare case of warm autoimmune hemolytic anemia triggered by Epstein-Barr virus reactivation in a 62-year-old male.

December 8, 2025BloodOpen Access

Warm autoimmune hemolytic anemia following epstein-barr virus reactivation: An uncommon clinical association

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Case report reveals warm autoimmune hemolytic anemia linked to Epstein-Barr virus reactivation, indicating treatment success with corticosteroids.

To report a rare case of warm autoimmune hemolytic anemia triggered by Epstein-Barr virus reactivation in a 62-year-old male.
Case report of a 62-year-old male with abnormal liver and kidney function tests and clinical symptoms.
Laboratory tests revealed significant anemia and hemolysis markers, including low haptoglobin and high lactate dehydrogenase.
Direct antiglobulin test confirmed the presence of IgG on red blood cells.
Treatment involved prednisone and phenotype-matched red blood cell transfusion.
Patient presented with hemoglobin of 6.6 g/dL and leukocytosis of 14,300/mm³.
Epstein-Barr virus reactivation was confirmed; treatment led to clinical improvement.
Clinical and laboratory parameters improved, with normalization of hemolysis markers after treatment.

Felix Lee (2025) studied this question.

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Case report reveals warm autoimmune hemolytic anemia linked to Epstein-Barr virus reactivation, indicating treatment success with corticosteroids.