What question did this study set out to answer?

This research aims to explore the relationship between urinary gene expression and kidney dysfunction in sickle cell disease.

December 8, 2025BloodOpen Access

Gene expression profiles of the nephron by urine mRNA: A liquid biopsy to investigate molecular changes in sickle cell nephropathy

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Authors

MRMaria Armila RuizUniversity of Illinois Chicago LSL. Castrillo SalasUniversity of Illinois Chicago ZIZalaya IvyUniversity of Illinois Chicago

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Implication

Findings reveal urine mRNA gene expression links to kidney dysfunction in adults with sickle cell disease, suggesting hypertension impacts nephron health.

Key Points

This research aims to explore the relationship between urinary gene expression and kidney dysfunction in sickle cell disease.
Collected urine samples from 50 adults with sickle cell disease.
Isolated mRNA and analyzed gene expression of nephron segments using real-time PCR.
Assessed statistical associations between mRNA expression and clinical variables using linear regression.
Increased AQP2 expression was linked to elevated blood pressure.
Higher NPHS1 expression correlated with increased urine albumin-to-creatinine ratio and worsening kidney function.
54% of participants had chronic kidney disease, highlighting the significance of nephron stress biomarkers.

Cite This Study

Ruiz et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1ba https://doi.org/10.1182/blood-2025-529

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Implication

Findings reveal urine mRNA gene expression links to kidney dysfunction in adults with sickle cell disease, suggesting hypertension impacts nephron health.

Gene expression profiles of the nephron by urine mRNA: A liquid biopsy to investigate molecular changes in sickle cell nephropathy

Discussion

Member takes

Implication

Key Points

Cite This Study

Gene expression profiles of the nephron by urine mRNA: A liquid biopsy to investigate molecular changes in sickle cell nephropathy

Discussion

Member takes

Implication

Key Points

Cite This Study

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