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December 8, 2025BloodOpen Access

RNA-sequencing improves risk stratification and guides treatment decision-making in acute lymphoblastic leukemia- a UK single centre experience

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Authors

RGRajeev GuptaKXKe Xu

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Overview

Retrospective analysis shows RNA-sequencing improves risk stratification and guides treatment decisions in acute lymphoblastic leukemia.

Key Points

  • This research evaluates the impact of RNA sequencing on risk stratification and treatment decisions in acute lymphoblastic leukemia.
  • Retrospective review of clinical and molecular data from 121 ALL patients
  • Routine RNA-sequencing integrated into diagnostic workflow
  • Assessment of clinical impact of RNA-seq on risk stratification and MRD monitoring
  • RNA-seq detected 38 gene fusions, enhancing risk stratification for 5% of patients
  • Integrated MRD tracking revealed unique fusions in patients without conventional MRD markers
  • 20% of treatment decisions were influenced by RNA-seq findings

Cite This Study

Gupta et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d20ehttps://doi.org/10.1182/blood-2025-6878
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