What question did this study set out to answer?

To assess obstetric and hemostatic outcomes in women with Hemophilia A or B during pregnancy and delivery.

December 8, 2025BloodOpen Access

Pregnancy and delivery outcomes in women with Hemophilia A and B: A multicenter cohort study from the Italian association of haemophilia centers

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To assess obstetric and hemostatic outcomes in women with Hemophilia A or B during pregnancy and delivery.
Retrospective cohort study from seven haemophilia reference centers in Italy.
Eligibility included women with confirmed Hemophilia A or B diagnoses and a history of pregnancy.
Data collected included demographic, clinical, and obstetric outcomes.
The study analyzed bleeding events, delivery modes, and hemostatic treatments.
94 women enrolled; 174 pregnancies with diverse outcomes: 95 vaginal deliveries, 59 cesarean sections, and 10 miscarriages.
Bleeding complications occurred in 12 pregnancies; postpartum hemorrhage documented in 20 cases.
Transfusions needed in 3 cases due to postpartum hemorrhage; genetic counseling uptake remains low.

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Multicenter cohort study finds high rates of postpartum hemorrhage in women with hemophilia, suggesting need for improved prenatal care.

Mattana et al. (2025) studied this question.

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