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December 8, 2025BloodOpen Access

Real-world treatment and safety outcomes of patients with Mantle Cell Lymphoma in the United States

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Authors

YLYang LiuAPAndrew S. ParkDBDaniela Benítez-Cano

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Overview

Retrospective analysis reports treatment patterns and safety profiles for MCL patients, suggesting urgent need for novel therapies.

Key Points

  • To describe treatment patterns and safety profiles of adult patients with Mantle Cell Lymphoma in real-world settings.
  • Conducted a retrospective cohort analysis of adult MCL patients from 2013 to 2023 using Optum Market Clarity data.
  • Included patients with specific ICD-10 codes and treatment history.
  • Assessed treatments based on NCCN guidelines and identified adverse events using ICD codes.
  • Included 1,936 MCL patients with median follow-up of 28 months; 71% were male and 81% Caucasian.
  • 89% were treated with Rituximab-based regimens; 85% in the first line.
  • 66% of patients developed infections; significant cardiovascular events such as hypertension were commonly observed.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d27fhttps://doi.org/10.1182/blood-2025-1795
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world treatment utilization, sequencing, and outcomes in Mantle Cell Lymphoma: Emerging treatment patterns in the United States2025
  2. 2Nationwide Assessment of Patient Trajectories in Mantle Cell Lymphoma: The Swedish MCLcomplete Project2023 · 16 citations
  3. 3Initial treatment patterns and survival outcomes in patients with Mantle Cell Lymphoma in the era of BTK inhibitors: A multicenter real-world study2025
  4. 4Real-world treatment patterns, patient characteristics, and outcomes of cbtki-based therapies amongst a contemporary cohort of patients with R/R MCL in the United States2025
  5. 5Treatment patterns and survival outcomes in patients with Mantle Cell Lymphoma: Interim report of the Asia-Pacific multinational prospective registry study2025 · 1 citations