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December 8, 2025Blood

Disparities in survival outcomes among adolescent and young adults vs adult populations with Hodgkin lymphoma: A population based SEER study

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Authors

SJSalman Ayub JajjaJTJatin ThukralALAmanda Lussier

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Overview

Population-based analysis reveals significant survival differences by age, race, and rurality, suggesting urgent need for targeted interventions.

Key Points

  • To examine disparities in overall survival among Hodgkin lymphoma patients across different demographics and treatment delays.
  • Utilized SEER database to analyze data from 32,483 HL patients aged ≥15 years
  • Grouped patients by age, sex, race/ethnicity, and rurality
  • Calculated overall survival using Kaplan–Meier analysis and Cox proportional hazards models
  • Identified median follow-up time and time to treatment initiation
  • Five-year overall survival was 85.5% overall, with better rates in AYAs (88%) compared to MidAge (75%) and Older (46%)
  • Significant survival differences reported based on race and rurality
  • Conditional five-year overall survival remained >90% in AYAs after 60 months; declined in Older patients

Cite This Study

Jajja et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d2d0https://doi.org/10.1182/blood-2025-5406
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Survival trends and disparities in indolent and aggressive non-Hodgkin lymphoma.2026
  2. 2Long term outcomes of older patients with classical hodgkin lymphoma: an analysis of the Texas cancer registry2025
  3. 3Overall survival differences by treatment setting in older adults with classical Hodgkin lymphoma: A National Cancer Database analysis.2026
  4. 4Clinical characteristics and outcomes of Hodgkin Lymphoma: A single institution retrospective cohort study2026
  5. 5Racial and geographic disparities in Hodgkin lymphoma mortality among adolescents and young adults in the United States, 1999-2023.2026