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December 8, 2025BloodOpen Access

Outcomes of patients with dual primary T-cell and B-cell lymphoid malignancies

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Authors

CTColin ThomasUPMC Hillman Cancer CenterSNSunita D. NastaUniversity of PennsylvaniaJSJakub SvobodaUPMC Hillman Cancer Center

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Overview

Retrospective analysis highlights autoimmune conditions and clonal hematopoiesis in dual lymphoid malignancies.

Key Points

  • This study aims to investigate the clinical characteristics and outcomes of patients with dual primary T-cell and B-cell lymphoid malignancies.
  • Ongoing retrospective study across multiple academic centers
  • Involvement of patients over 18 with mature T-cell and B-cell malignancies
  • Assessment of clinical characteristics and outcomes of dual malignancies
  • Identified 40 patients with dual B- and T-cell lymphoid malignancies
  • 60% of patients were male with a median age at first diagnosis of 64 years
  • Clonal hematopoiesis mutations detected in 35% of patients

Cite This Study

Thomas et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d2d5https://doi.org/10.1182/blood-2025-5409
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