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December 11, 2025DiagnosticsOpen Access

Association of Secondary Primary Malignancies in Cutaneous Lymphoma: A Narrative Review

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Authors

YHYu-Hsiang HungMackay Memorial HospitalPHPa‐Fan HsiaoMackay Memorial Hospital

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Implication

Narrative review reveals elevated risks of second primary malignancies in cutaneous lymphoma, suggesting need for enhanced patient education and monitoring.

Key Points

  • This review examines the incidence and risk factors of second primary malignancies in cutaneous lymphoma.
  • Narrative review of current literature on cutaneous lymphomas and second primary malignancies.
  • Analysis of population-based and institutional studies regarding malignancy risks.
  • Synthesis of mechanisms for second primary malignancies, including genetic and treatment factors.
  • Increased incidence of hematologic tumors and solid tumors in patients with cutaneous T-cell lymphomas.
  • Limited data on second primary malignancies in cutaneous B-cell lymphomas, but some risks identified.
  • Emphasizes the need for vigilant patient monitoring and education to manage second primary malignancy risks.

Cite This Study

Hung et al. (2025) studied this question.

synapsesocial.com/papers/694019342d562116f28f6df7https://doi.org/10.3390/diagnostics15243150
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