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December 8, 2025Blood

Diffuse large B cell lymphoma: A study of second primary malignancies among adults in the United States

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Authors

OOOboseh John OgedegbeACAsfand Yar CheemaAOAyobami Gbenga Olafimihan

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Overview

Analysis reveals increased risk of second primary malignancies in DLBCL patients, suggesting need for screening.

Key Points

  • The research aims to evaluate the risk of second primary malignancies in patients with diffuse large B cell lymphoma.
  • Analyzed data from the SEER database on DLBCL cases diagnosed from 2000 to 2022.
  • Defined second primary malignancy as occurring six months after an index DLBCL diagnosis.
  • Calculated O/E ratios and AER for SPM rates.
  • 9,893 out of 134,366 DLBCL cases developed second primary malignancies (7.4%).
  • The O/E ratio for developing SPM was 1.29 (CI 1.27-1.32).
  • The most common SPM included thyroid cancer (O/E ratio 2.12) and acute myeloid leukemia (O/E ratio 6.25).

Cite This Study

Ogedegbe et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4bdhttps://doi.org/10.1182/blood-2025-3680
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Racial/ethnic disparities in risk of second primary malignancies among Diffuse Large B-cell Lymphoma survivors.2026
  2. 2Second primary malignancies in patients with chronic lymphocytic leukemia: A SEER analysis, 2000–2022.2026
  3. 3Risk of second primary malignancies among CLL survivors across treatment eras: A SEER-based study with racial and ethnic stratification2025
  4. 4Incidence and survival of second primary non-Hodgkin lymphoma: A Surveillance, Epidemiology, and End Results-based cohort study2024 · 1 citations
  5. 5Analysis of Second Primary Tumours in Cutaneous Lymphoma Populations2026