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December 8, 2025BloodOpen Access

Characterization of bone marrow B-cells in patients with warm autoimmune hemolytic anemia by single-cell analysis

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Authors

FLFrancesca LazzaroniNBNiccolò BolliWBWilma Barcellini

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Overview

Single-cell RNA sequencing reveals B-cell gene expression changes in warm autoimmune hemolytic anemia, indicating potential therapeutic targets.

Key Points

  • This research aims to characterize bone marrow B-cells in patients with warm autoimmune hemolytic anemia using single-cell RNA sequencing.
  • Performed single-cell RNA sequencing on bone marrow samples from 9 wAIHA patients and 4 healthy donors.
  • Included longitudinal sampling of 3 patients at various stages: diagnosis, remission, and relapse.
  • Analyzed B-cell subpopulations and gene expression associated with disease stages.
  • B-cell subpopulations were enriched in wAIHA patients compared to healthy donors.
  • Immature B-cells increased at remission and relapse, while mature B-cells were elevated at diagnosis.
  • Key gene expression changes linked to immune response and cell proliferation were observed, suggesting novel therapeutic targets.

Cite This Study

Lazzaroni et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d327https://doi.org/10.1182/blood-2025-1122
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bone marrow microenvironment in autoimmune hemolytic anemia: from trephine biopsy to single cell RNA sequencing2025 · 4 citations
  2. 2[Future directions in the management of warm autoimmune hemolytic anemia].2025
  3. 3Real-world evidence from China: Clinical characteristics, treatment landscape and long-term outcomes in 566 autoimmune hemolytic anemia patients2025
  4. 4Heterogeneity of treatment regimens and related health resource use in managing patients with waiha: A US multi-database retrospective observational Study2025
  5. 5Delayed Autoimmune Hemolytic Anemia After Remission in Non-Hodgkin Lymphoma2026