What type of study is this?

This is a Human Clinical Trial study.

December 8, 2025BloodOpen Access

Overcoming barriers to clinical trial enrollment among adolescents and young adults with acute myeloid leukemia: Insights from a large academic cancer center

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Authors

MSMahesh SwaminathanThe University of Texas MD Anderson Cancer Center KSKoji SasakiThe University of Texas MD Anderson Cancer Center TKTapan KadiaThe University of Texas MD Anderson Cancer Center

Discussion

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Implication

Retrospective analysis reveals barriers hindering clinical trial enrollment in adolescents and young adults with acute myeloid leukemia, suggesting financial support and eligibility criteria need to改善

Key Points

To identify barriers affecting clinical trial enrollment among adolescents and young adults (AYAs) with acute myeloid leukemia (AML).
Retrospective review of AYA patients with AML at MD Anderson Cancer Center from 2013 to 2023
Analysis of sociodemographic and clinical data from electronic medical records
Characterization of non-enrollment reasons from physician notes
71% of AYAs with AML were enrolled in clinical trials
Most common barriers included insurance/financial constraints (33%) and ineligibility due to patient factors (22%)
Treatment on a clinical trial was associated with a significantly lower hazard of death (HR-0.46, p=0.001) compared to those treated outside of trials

Cite This Study

Swaminathan et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d399 https://doi.org/10.1182/blood-2025-4613

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Overcoming barriers to clinical trial enrollment among adolescents and young adults with acute myeloid leukemia: Insights from a large academic cancer center

Discussion

Member takes

Implication

Key Points

Cite This Study

Overcoming barriers to clinical trial enrollment among adolescents and young adults with acute myeloid leukemia: Insights from a large academic cancer center

Discussion

Member takes

Implication

Key Points

Cite This Study

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