Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
December 8, 2025Blood

Racial disparities in clinical outcomes among patients with newly diagnosed and relapsed multiple myeloma in the United States: A 21-year comparative analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

TVTarfa VerinumbeCUChidiebube UgwuEOElvis Obomanu

Discussion

Loading...

Member takes

Overview

Comparative analysis reveals higher risks of stroke and CKD among Black patients with multiple myeloma, implying complex care needs.

Key Points

  • This study evaluates racial disparities in clinical outcomes for newly diagnosed and relapsed multiple myeloma patients in the US.
  • Analyzed data from the TriNetX US Collaborative Network
  • Included adults (≥18 years) with newly diagnosed or relapsed multiple myeloma
  • Patients were grouped by self-identified race and propensity score matched based on age, sex, and comorbidities
  • Outcomes measured included all-cause mortality, hospitalization, neurologic events, CKD, heart failure and osteoporosis
  • Utilized log binomial regression to calculate risk ratios and confidence intervals.
  • Black patients had significantly higher risks of stroke, CKD, and heart failure compared to White patients
  • Lower all-cause mortality seen in Black patients compared to White
  • Asian patients had significantly lower hospitalization rates and risks of seizure and osteoporosis compared to White
  • Overall racial disparities highlighted, with Black patients facing more complications yet showing improved survival.

Cite This Study

Verinumbe et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3bchttps://doi.org/10.1182/blood-2025-4600
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Racial disparities in treatment initiation and early outcomes among patients with multiple myeloma: A real-world, multi-institutional cohort study2025
  2. 2Racial disparities in incidence and outcome in multiple myeloma: a population-based study2010 · 413 citations
  3. 3Outcomes for black persons with multiple myeloma: A national retrospective trend analysis from 2015 to 20222025
  4. 4Racial Differences in Outcomes Among Patients with Multiple Myeloma Treated at a Myeloma Center of Excellence: A Retrospective Cohort Study2026
  5. 5Survival shifts in multiple myeloma: Evaluating the impact of therapeutic advances and racial disparities after a decade of change.2024 · 1 citations