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This study aims to identify predictors of overall survival and new conduction disease in patients with AL cardiac amyloidosis.

December 8, 2025Blood

Distinct predictors of mortality and conduction disease in AL cardiac amyloidosis

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This study aims to identify predictors of overall survival and new conduction disease in patients with AL cardiac amyloidosis.
Single-center retrospective cohort study of patients with biopsy- or imaging-confirmed AL cardiac amyloidosis
Analyzed data from 2008 to 2024
Multivariable Cox proportional hazards models assessed baseline covariates and outcomes
62 of 128 at-risk patients developed a new conduction abnormality over 36 months
Chemotherapy significantly improved survival (HR 0.27) and reduced conduction disease risk (HR 0.17)
Age, NYHA class, and Mayo Stage were significant predictors of mortality but not conduction disease

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Retrospective cohort study identifies risk stratification factors impacting survival and conduction abnormalities in al cardiac amyloidosis patients.

Safdar et al. (2025) studied this question.

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Retrospective cohort study identifies risk stratification factors impacting survival and conduction abnormalities in al cardiac amyloidosis patients.