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December 8, 2025BloodOpen Access

Can we perform allogeneic hematopoietic cell transplantation (HCT) safely in patients with limited social supports and substantial psychosocial complexity?

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Authors

NTNicolas K. TradMassachusetts General HospitalJSJ. Mark SloanBoston UniversityRNRichard NewcombHarvard University

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Implication

Retrospective cohort study shows good overall survival in HCT patients with social support issues, suggesting safe transplantation practices.

Key Points

  • The study aims to evaluate clinical outcomes of allogeneic HCT in patients with limited social support and high psychosocial complexity.
  • Conducted a retrospective cohort study of adult patients undergoing allogeneic HCT at a single academic center.
  • Data included demographic, disease-related, and transplant-related information and clinical outcomes.
  • Outcomes assessed included overall survival, cause of death, and the incidence of acute and chronic GVHD.
  • 37.1% of 506 HCT recipients had limited social support.
  • 12-month overall survival was similar between patients with limited and high social support (79.2% vs. 81.7%).
  • Psychosocial complexity showed a modest association with lower overall survival (HR 1.09, p = 0.04).

Cite This Study

Trad et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3c2https://doi.org/10.1182/blood-2025-4617
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pre-emptive multidisciplinary approach to overcome the negative impact of high psychosocial risk factor on outcomes after allogeneic hematopoietic cell transplantation2025
  2. 2Psychosocial well-being in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) and their caregivers: A prospective study2025
  3. 3Hematopoietic Stem-Cell Transplantation: Exploring the Latest Advances and Gaps in Disparities, Psychosocial and Symptom Management Interventions, and Chronic Graft-Versus-Host Disease Care2024 · 16 citations
  4. 4Abstract C044: Social vulnerability is an important predictor of cardiovascular disease risk after allogeneic hematopoietic cell transplantation2024
  5. 5Effect of race and socio-economic status in allogeneic STEM cell transplantation. a single center experience.2025