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December 8, 2025BloodOpen Access

Altered osteoblast populations dynamics underlie myeloma progression from precursors diseases in bone microenvironment

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Authors

FMForogh MohammadiIslamic Azad University of KermanshahAGAlessandro GuidiFondazione IRCCS Istituto Nazionale dei TumoriAPAndrea PolettiUniversity of Parma

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Implication

Single-cell analysis reveals osteoblastogenesis disruption in monoclonal gammopathy, indicating immunosuppressive BME changes.

Key Points

  • This study aims to characterize the dynamics of osteoblast populations in multiple myeloma progression from precursor diseases.
  • Conducted a single-cell transcriptomic characterization of osteoblastic cells from bone biopsies.
  • Analyzed 16 bone biopsies of patients with monoclonal gammopathy, smoldering multiple myeloma, and newly diagnosed multiple myeloma.
  • Used scRNAseq to enrich non-hematopoietic cells and identify differentially expressed markers.
  • Identified distinct osteoblast lineage clusters with varying functional characteristics across disease stages.
  • Notable depletion of functional pre-OBs WISP2+ correlated inversely with tumor burden.
  • Expanded dysfunctional pre-OBs exhibited enhanced immunosuppressive properties and altered metabolic processes.

Cite This Study

Mohammadi et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3d3https://doi.org/10.1182/blood-2025-4958
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 6848: Analysis of the bone microenvironment cells by single cell transcriptomics reveals altered features in multiple myeloma patients compared to pre-malignant monoclonal gammopathies2024
  2. 2Single-cell sequencing reveals transcriptional and metabolic divergence of bone-involved multiple myeloma2025
  3. 3Transcriptional Remodeling of the Stromal and Endothelial Microenvironment in MGUS to Multiple Myeloma Progression2024 · 6 citations
  4. 4Stromal and endothelial transcriptional changes during progression from MGUS to myeloma and after treatment response2026
  5. 5Single‑cell Transcriptomic Profiling of Bone Marrow Mesenchymal Stem Cells Reveals Lineage Heterogeneity and Dysregulated Osteoblast Genesin Osteoporosis Versus Osteoarthritis2026