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December 8, 2025BloodOpen Access

Proportion of second hematologic malignancies linked to radiotherapy treatment in adults: A cohort study in the US SEER cancer registries 2001-2022

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Authors

ASAbhay SinghCleveland Clinic

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Implication

Cohort analysis shows 1.3% of second hematologic malignancies link to radiotherapy in cancer survivors, highlighting long-term risks.

Key Points

  • The aim is to estimate the proportion of second hematologic malignancies attributable to radiotherapy in cancer survivors.
  • Population-based cohort study using SEER data from 2001 to 2022
  • Included patients diagnosed with 15 solid tumors treated with radiotherapy
  • Follow-up for at least five years post first cancer diagnosis
  • Relative risk assessed using Poisson regression, adjusted for various confounders
  • Identified 2,221,476 adult cancer survivors with a mean follow-up of 11 years
  • 13.6% developed a second primary cancer; 1.3% were second hematologic malignancies
  • Non-Hodgkin lymphoma was the most common second hematologic cancer
  • Radiotherapy linked to increased risk of hematologic malignancies for certain cancers, particularly thyroid and breast

Cite This Study

Abhay Singh (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3d9https://doi.org/10.1182/blood-2025-4637
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Also Consider

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  4. 4Age-Specific Risk of Second Primary Malignant Neoplasm After Radioactive Iodine Treatment for Differentiated Thyroid Cancer2025 · 4 citations
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