What type of study is this?

This is a Cohort Study study (also classified as: Human Clinical Trial, In Vitro Study, Pre-Registered Trial, Validation Study).

What question did this study set out to answer?

This research aims to evaluate the feasibility and effectiveness of a high throughput drug sensitivity assay in predicting treatment responses in relapsed/refractory multiple myeloma.

December 8, 2025Blood

A functional precision medicine clinical trial in Relapsed/Refractory multiple myeloma: Prospective study of a high throughput drug sensitivity assay on correlation of drug sensitivity scores with treatment response

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Authors

RDRyan F. DonnellyCollege of the Holy Cross RBRahul BanerjeeUniversity of Washington ACAndrew J. CowanCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa

Discussion

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Implication

Functional precision medicine improves treatment response prediction in relapsed multiple myeloma, suggesting personalized approaches may enhance outcomes.

Key Points

This research aims to evaluate the feasibility and effectiveness of a high throughput drug sensitivity assay in predicting treatment responses in relapsed/refractory multiple myeloma.
Conducted a prospective clinical trial with eligible relapsed/refractory multiple myeloma patients.
Utilized a high throughput drug sensitivity assay on isolated CD138+ plasma cells to determine drug sensitivity scores for various agents.
Employed receiver operator analysis to assess the ability of drug sensitivity scores to predict treatment outcomes.
Enrolled 40 patients with high prior exposure to common therapies, achieving an overall response rate of 51.4%.
Median progression free survival for all patients was 5.7 months, indicating variable treatment responses.
Drug sensitivity scores showed a non-significant tendency toward higher values in responders receiving selinexor compared to non-responders.

Cite This Study

Donnelly et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3fc https://doi.org/10.1182/blood-2025-7446

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Implication

Functional precision medicine improves treatment response prediction in relapsed multiple myeloma, suggesting personalized approaches may enhance outcomes.

A functional precision medicine clinical trial in Relapsed/Refractory multiple myeloma: Prospective study of a high throughput drug sensitivity assay on correlation of drug sensitivity scores with treatment response

Discussion

Member takes

Implication

Key Points

Cite This Study

A functional precision medicine clinical trial in Relapsed/Refractory multiple myeloma: Prospective study of a high throughput drug sensitivity assay on correlation of drug sensitivity scores with treatment response

Discussion

Member takes

Implication

Key Points

Cite This Study

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