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December 8, 2025Blood

A rapid gene expression profiler predicts tumor responsiveness and patient outcome for standard-of-care therapies in acute myeloid leukemia

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Authors

SNStanley NgJWJean WangJDJohn E. Dick

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Overview

Gene expression profiling predicts tumor responsiveness and improves patient outcomes in acute myeloid leukemia, indicating potential for enhanced treatment selection.

Key Points

  • To evaluate the effectiveness of a gene expression-based profiler in predicting tumor responsiveness and patient outcomes in acute myeloid leukemia.
  • Developed Myelo-ID assay for profiling leukemia stemness and tumor differentiation states.
  • Used RNA from AML patient mononuclear cells for quantitative PCR analysis and profiling.
  • Performed regression analyses to identify predictors of treatment response and overall survival.
  • Identified distinct tumor cell states associated with response to therapies.
  • High BCL2 gene expression was a significant predictor of survival outcomes.
  • Combination of clinical and genetic features improved predictive accuracy for treatment responses.

Cite This Study

Ng et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d40dhttps://doi.org/10.1182/blood-2025-657
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