What question did this study set out to answer?

To evaluate the impact of different GVHD prophylaxis strategies on transplantation outcomes in adults with chronic active EBV infection.

December 8, 2025Blood

Different graft-vs-host disease prophylaxis strategy for allogeneic hematopoietic stem cell transplantation in adults with chronic active EBV infection

View Full Paper

Ask AI

Bookmark

To evaluate the impact of different GVHD prophylaxis strategies on transplantation outcomes in adults with chronic active EBV infection.
Retrospective review of patients receiving allo-HSCT at Tongji Hospital
Comparison of anti-thymocyte globulin (ATG) vs. ATG plus post-transplant cyclophosphamide (ATG+PTCy)
Analysis of overall survival and GVHD incidences
5-year overall survival was 54.5%, progression-free survival was 39.4%
ATG+PTCy reduced grade II-IV acute GVHD incidence compared to ATG alone
Pre-transplant hemophagocytic syndrome and higher EBV copies negatively impacted overall survival.

No takes yet. Share an insight, caveat, or question.

Retrospective review shows anti-thymocyte globulin plus cyclophosphamide improves outcomes in adults with chronic active EBV infection.

Wei et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark