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December 8, 2025Blood

The B2M–LILRB1 axis as a novel myeloid immune checkpoint and therapeutic target in multiple myeloma

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Authors

PFPietro FolinoPRPaola RampaRSRita Starace

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Overview

Functional analysis reveals immune checkpoint role of B2M in multiple myeloma, suggesting targeting LILRB1 may enhance phagocytosis.

Key Points

  • This research aims to investigate the role of the B2M-LILRB1 axis as a myeloid immune checkpoint in multiple myeloma.
  • Screened IPC axes in MM cells and APCs using bone marrow aspirates via multiparametric flow cytometry.
  • Performed immunophenotyping for MM cells and APCs covering IPC and lineage markers.
  • Conducted phagocytosis assays on MM cell lines with manipulated B2M expression.
  • Identified B2M-LILRB1 axis as a dominant IPC in MM.
  • B2MKO and B2MMUT MM cells exhibited over two-fold increased susceptibility to phagocytosis by dendritic cells.
  • LILRB1 knockdown in APCs enhanced phagocytic potential after treatment with Bortezomib.

Cite This Study

Folino et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d428https://doi.org/10.1182/blood-2025-1032
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1LILRB4 drives proinflammatory cytokine secretion in multiple myeloma to promote the immune-cell dysfunction via the generation of myeloid-derived suppressive cells2025
  2. 2Deciphering the cellular hierarchy of multiple myeloma uncovers a therapeutically exploitable EP300/TBX2 axis in LILRB4+ myeloma-initiating cells2025
  3. 3Abstract 364: Targeting LILRB1 to sensitize human myeloma to ferroptosis through disrupting cholesterol homeostasis2024
  4. 4LILRB4 represents a promising target for immunotherapy by dual targeting tumor cells and myeloid-derived suppressive cells in multiple myeloma2024 · 12 citations
  5. 5LILRB4 regulates multiple myeloma development through STAT3-PFKFB1 pathway2024 · 12 citations