Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 18, 2024Cell Death and DiseaseOpen Access

LILRB4 regulates multiple myeloma development through STAT3-PFKFB1 pathway

View Full Paper
Ask AI
Bookmark
Share

Authors

LXLi XieCCChiqi ChenTZTinghua Zhang

Discussion

Loading...

Member takes

Overview

Preclinical analysis demonstrates that LILRB4 promotes multiple myeloma growth via STAT3-PFKFB1 signaling, suggesting a viable target for immunotherapy-resistant disease.

Key Points

  • Leukocyte immunoglobulin-like receptor B4 expression is elevated in multiple myeloma, correlating adversely with patient overall survival and accelerating tumor proliferation.
  • Knockdown of LILRB4 efficiently delayed multiple myeloma cell growth both in vitro and in vivo, operating downstream of IKZF1 through activation of the STAT3-PFKFB1 pathway.
  • Therapeutic blockade using LILRB4 antibodies suppresses multiple myeloma progression, supporting a viable strategy for refractory disease; in vivo preclinical models warrant validation.

Cite This Study

Xie et al. (2024) studied this question.

synapsesocial.com/papers/68e5fc83b6db643587590e7ahttps://doi.org/10.1038/s41419-024-06883-4
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1LILRB4 regulates multiple myeloma development through STAT3-PFKFB1 pathway2024
  2. 2LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway2024 · 20 citations
  3. 3LILRB4 represents a promising target for immunotherapy by dual targeting tumor cells and myeloid-derived suppressive cells in multiple myeloma2024 · 12 citations
  4. 4LILRB4 drives proinflammatory cytokine secretion in multiple myeloma to promote the immune-cell dysfunction via the generation of myeloid-derived suppressive cells2025
  5. 5Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis2024 · 36 citations