What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

This research investigates the effectiveness of high-dose vitamin C in managing hematological malignancies. The goal is to evaluate its impact on survival outcomes and response rates in cancer therapy.

December 8, 2025BloodOpen Access

The role of high-dose vitamin c in management of hematological malignancies: Asystematic review and meta-analysis

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This research investigates the effectiveness of high-dose vitamin C in managing hematological malignancies. The goal is to evaluate its impact on survival outcomes and response rates in cancer therapy.
Conducted a comprehensive literature search on multiple databases following PRISMA guidelines.
Included 19 studies that used vitamin C as adjunct to chemotherapy in hematological malignancies.
Calculated inter-study variance using the DerSimonian-Laird estimator, analyzing pooled survival data using R programming.
Pooled median overall survival was 34.42 months, with significant survival rates at various time points.
Vitamin C demonstrated a complete response rate of 20% and an overall response rate of 41% in the included studies.
Progression-free survival showed a median of 14.09 months, indicating promising outcomes with high-dose vitamin C.

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Implication

Meta-analysis shows high-dose vitamin C improves overall survival in cancer, suggesting its role in treatment.

Cite This Study

Sattar et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d430 https://doi.org/10.1182/blood-2025-8116

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The role of high-dose vitamin c in management of hematological malignancies: Asystematic review and meta-analysis

Key Points

Discussion

Implication

Cite This Study

The role of high-dose vitamin c in management of hematological malignancies: Asystematic review and meta-analysis

Key Points

Discussion

Implication

Cite This Study

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