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December 8, 2025Blood

Racial, geographic, and gender disparities in ischemic heart disease mortality in patients with multiple myeloma: A nationwide analysis (1999–2023).

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Authors

SCSaira ChaughtaiABAli BhattiZQZaheer Qureshi

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Overview

Nationwide analysis reveals increased mortality rates in African American men with ischemic heart disease in multiple myeloma patients, suggesting urgent need for tailored interventions.

Key Points

  • To analyze trends in ischemic heart disease mortality among patients with multiple myeloma from 1999 to 2023, highlighting disparities based on sex, race/ethnicity, and age.
  • Nationally representative data from the CDC WONDER database for U.S. adults aged ≥25 years
  • Inclusion of decedents with multiple myeloma and ischemic heart disease listed on death certificates
  • Calculation of age-adjusted mortality rates and use of Joinpoint regression for trend analysis
  • 30,107 deaths involving both multiple myeloma and ischemic heart disease identified
  • Overall age-adjusted mortality rate was 5.72 per million, with significant trends observed
  • Black or African American individuals had the highest mortality rate, showing a significant decline over time.

Cite This Study

Chaughtai et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d434https://doi.org/10.1182/blood-2025-8114
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Projected trends in ischemic heart disease mortality among patients with multiple myeloma in the United States: A forecast analysis through 2035.2026
  2. 2Temporal trends and disparities in cardiovascular disease-related mortality among adults with multiple myeloma in the United States, 1999–20232025 · 3 citations
  3. 3Rising mortality trends in elderly multiple myeloma patients with hypertension: A CDC wonder database analysis (1999–2023)2025
  4. 4Mortality trend from multiple myeloma with hypertensive diseases as a contributing cause in the United States, 1999–2024: A CDC WONDER analysis across age, sex, and geographic variables.2026
  5. 5Demographics and regional trends of ischemic heart disease-related mortality in older adults in the United States, 1999–20202025 · 7 citations