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December 8, 2025BloodOpen Access

DNA-proximal MYB phosphorylation is required for oncogenic transcription in acute myeloid leukemia

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Authors

SCShuyuan ChengMUMasahiro UniRKRichard P. Koche

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Overview

Findings reveal phosphorylation regulates MYB transcription factors in acute myeloid leukemia, suggesting new therapeutic targets.

Key Points

  • This research investigates the role of MYB phosphorylation in the transcriptional regulation of acute myeloid leukemia (AML).
  • Analyzed post-translational modifications of MYB proteins isolated from human AML cells.
  • Employed high-resolution mass spectrometry for MYB peptide sequence identification and modification assessment.
  • Validated phosphorylation through mutagenesis and phospho-specific antibodies.
  • Identified S11/S12 phosphorylation as essential for MYB functionality in AML cells.
  • Phosphorylated MYB was associated with various transcription factors in leukemia populations.
  • Demonstrated potential for targeted therapies against MYB-mediated transcriptional circuits.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4aehttps://doi.org/10.1182/blood-2025-3239
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