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December 8, 2025Blood

Replacing FISH with a comprehensive integrated approach for tumor genotyping and immune monitoring in multiple myeloma: The flagship study

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Authors

MMMark MeersonMBMainak BardhanJHJames E. Hoffman

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Overview

Integrated approach improves tumor genotyping and immune monitoring in multiple myeloma, indicating advanced diagnostic capabilities.

Key Points

  • Evaluate the feasibility of integrated sequencing approaches for tumor genotyping and immune monitoring in multiple myeloma.
  • Whole-exome sequencing with immunoglobulin heavy chain capture on bone marrow tumor cells
  • RNA sequencing on tumor cells and peripheral blood mononuclear cells
  • Analysis of genomic alterations and immune profiling using advanced algorithms
  • Integrated sequencing matched all detectable lesions from standard FISH tests
  • Identified additional actionable genomic abnormalities and immune profiles
  • Supported robust profiling even in low tumor content samples where FISH failed

Cite This Study

Meerson et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4c4https://doi.org/10.1182/blood-2025-7479
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comprehensive DNA/RNA-based targeted sequencing for molecular karyotyping and clonality assessment in newly diagnosed multiple myeloma patients2025
  2. 2Comprehensive characterization of multiple myeloma genomes from bone marrow or peripheral blood with a novel clinical assay enables identification of resistance mechanisms2025
  3. 3Abstract 1067: Whole genome sequencing of multiple myeloma genomes with a novel clinical assay enables identification of genetic alterations underlying immunotherapy resistance2026
  4. 4Integrated cell-free DNA and RNA sequencing recapitulates bone marrow genomic and transcriptomic alterations in multiple myeloma2025 · 1 citations
  5. 5Pilot study of whole-exome sequencing and single-nucleus RNA sequencing to identify actionable alterations in cancer.2026