What type of study is this?

This is a Human Clinical Trial study (also classified as: Phase 3).

What question did this study set out to answer?

To examine how non-adherence to NCCN guidelines affects survival in patients eligible for CAR T-cell therapy for DLBCL.

December 8, 2025BloodOpen Access

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Simulation model reveals reduced survival in DLBCL patients not receiving CAR T therapy, highlighting guideline adherence issues.

To examine how non-adherence to NCCN guidelines affects survival in patients eligible for CAR T-cell therapy for DLBCL.
Constructed a patient-level simulation model using clinical trial data.
Projected long-term survival for CAR T-eligible patients based on NCCN criteria.
Simulated treatment scenarios with up to 75% misallocation of therapies.
Performed sensitivity analyses to evaluate varying degrees of treatment misallocation.
Estimated 6,299 eligible patients misallocated to non-recommended treatments with a 75% misallocation rate.
5-year overall survival for misallocated patients was 42%, compared to 54-57% for guideline-adherent patients.
Average reduction in life expectancy was 25 months per patient, leading to about 783 additional deaths in 5 years.

Kievit et al. (2025) studied this question.

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