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December 8, 2025Blood

Lymphocyte kinetics as a predictor of clinical outcomes following CAR-T therapy for non-Hodgkin lymphoma

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Authors

HGHelen GandlerARAnirudh RaoYSYuliya Shestovska

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Overview

Retrospective study associates lymphocyte kinetics and immune status with improved progression-free survival in non-Hodgkin lymphoma patients treated with CAR-T therapy, indicating potential for ALC's

Key Points

  • To evaluate lymphocyte kinetics as prognostic indicators of clinical outcomes following CAR-T therapy in patients with non-Hodgkin lymphoma.
  • Single-center, retrospective study
  • Evaluated lymphocyte kinetics in patients treated with axicabtagene ciloleucel
  • Median progression-free survival and overall survival were assessed
  • Rate of ALC expansion and AUC for lymphocyte kinetics were calculated
  • Patients with ALC above median at leukapheresis had significantly prolonged progression-free survival and overall survival
  • Higher ALC expansion rates correlated with better complete response rates
  • AUC for lymphocyte kinetics was associated with improved survival outcomes

Cite This Study

Gandler et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4eahttps://doi.org/10.1182/blood-2025-5506
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