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December 8, 2025BloodOpen Access

Absolute lymphocyte count is predictive of response to salvage therapies for post-CAR T failure

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Authors

HAHazim AbabnehANAndrea NgMFMatthew Frigault

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Overview

Retrospective analysis shows ALC correlates with treatment outcomes in relapsed large B-cell lymphoma, suggesting its role in risk stratification.

Key Points

  • Assess the predictive value of absolute lymphocyte count (ALC) on treatment outcomes after CAR T-cell therapy failure in large B-cell lymphoma.
  • Retrospective analysis of 352 LBCL patients receiving CAR T-cell therapy and subsequent salvage therapies.
  • Evaluation of ALC counts in relation to overall survival and progression-free survival following treatment.
  • Survival outcomes estimated using Kaplan-Meier method and compared using log-rank test.
  • Overall survival significantly higher in patients with late relapse (>6 months) compared to early relapse (≤6 months).
  • Complete response achieved by 46% of patients after the first salvage regimen.
  • Higher ALC at best response after first-line salvage therapy linked to improved overall survival and progression-free survival.

Cite This Study

Ababneh et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d584https://doi.org/10.1182/blood-2025-1928
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