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December 8, 2025BloodOpen Access

Title: Hacs1 is a myeloma immunosuppressor driving pro-tumorigenic myelopoiesis and myeloid cell differentiation through MS4A3/IL3/GM-CSF signaling

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Authors

RQRui QuDXDong XuXLXiaoyuan Liu

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Overview

Investigating Hacs1's impact on tumor progression in multiple myeloma, implicating myeloid derived suppressor cells in immune suppression.

Key Points

  • This research aims to explore the role of Hacs1 in the immunosuppressive microenvironment of multiple myeloma.
  • Utilized Hacs1-/- mouse BM-myeloid derived suppressor cells (MDSCs) and MM tumor-bearing mice.
  • Studied the regulation of immune responses and therapeutic resistance in myeloma progression.
  • Hacs1-/- mice showed increased PD-L1 expression in MDSCs, leading to suppressed T cell activity.
  • Overexpression of Hacs1 reduced MDSC accumulation, enhancing T cell function and decreasing tumor load.
  • Myeloid cells from Hacs1-/- mice expressed higher levels of signaling genes associated with MDSCs.

Cite This Study

Qu et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d50ahttps://doi.org/10.1182/blood-2025-7480
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