What question did this study set out to answer?

The aim was to assess the safety and feasibility of adding high dose methotrexate to R-CHOP for treating CNS involvement in large B-cell lymphoma.

December 8, 2025Blood

Safety and feasibility of high dose methotrexate addition to R-CHOP chemotherapy for prophylaxis and treatment of secondary cns involvement by large B-cell lymphoma in a community-based hospital setting

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Authors

TSTiba Al SagheerBaptist Hospital of Miami MRMuni RubensHeart Failure & Transplant NNNeil NagovskiBaptist Hospital of Miami

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Implication

Retrospective study shows high dose methotrexate improves progression-free survival in large B-cell lymphoma, indicating safety in community hospitals.

Key Points

The aim was to assess the safety and feasibility of adding high dose methotrexate to R-CHOP for treating CNS involvement in large B-cell lymphoma.
Retrospective study of 36 patients treated with MR-CHOP.
Patients divided into two groups: SCNSL (14) and CNS PPX (22).
MR-CHOP administered with HDMTX followed by CHOP in a modified sequence based on logistical needs.
Responses assessed by established criteria and survival outcomes analyzed using Kaplan-Meier methods.
In SCNSL group, the best complete response (CR) rate was 57.1% and overall response rate (ORR) was 71.4%.
1-year progression-free survival (PFS) was 60.6% and overall survival (OS) was 71.6% in SCNSL.
1-year PFS of 73.1% and OS of 90% in CNS prophylaxis group with median follow-up of 22 months.
Nephrotoxicity occurred in 16.6% of patients, leading to dose adjustments in 27.7% of cases.

Cite This Study

Sagheer et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d523 https://doi.org/10.1182/blood-2025-7195

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Implication

Retrospective study shows high dose methotrexate improves progression-free survival in large B-cell lymphoma, indicating safety in community hospitals.

Safety and feasibility of high dose methotrexate addition to R-CHOP chemotherapy for prophylaxis and treatment of secondary cns involvement by large B-cell lymphoma in a community-based hospital setting

Discussion

Member takes

Implication

Key Points

Cite This Study

Safety and feasibility of high dose methotrexate addition to R-CHOP chemotherapy for prophylaxis and treatment of secondary cns involvement by large B-cell lymphoma in a community-based hospital setting

Discussion

Member takes

Implication

Key Points

Cite This Study

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