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December 8, 2025Blood

Real world experience of anakinra for the treatment of immune effector cell-associated neurotoxicity syndrome in large B-cell lymphoma

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Authors

MSMinifrida SantiagoThe University of Texas MD Anderson Cancer Center MHMisha HawkinsThe University of Texas MD Anderson Cancer Center AAAmy AyersThe University of Texas MD Anderson Cancer Center

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Implication

Retrospective analysis shows anakinra improved outcomes in large B-cell lymphoma with high inflammatory biomarkers, suggesting potential in managing neurotoxicity.

Key Points

To evaluate the effectiveness of anakinra for treating immune effector cell-associated neurotoxicity syndrome in large B-cell lymphoma patients after CAR T-cell therapy.
Retrospective single-center analysis of patients with large B-cell lymphoma treated with anakinra for ICANS.
Collected baseline characteristics and inflammatory biomarkers post-CART infusion.
Graded CRS and ICANS per ASTCT criteria.
31 out of 42 patients (74%) responded to anakinra treatment for ICANS.
Non-responders showed significantly higher baseline inflammatory biomarkers compared to responders.
CRS-related mortality declined in patients treated with anakinra after its introduction.

Cite This Study

Santiago et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d567 https://doi.org/10.1182/blood-2025-6319

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Implication

Retrospective analysis shows anakinra improved outcomes in large B-cell lymphoma with high inflammatory biomarkers, suggesting potential in managing neurotoxicity.

Real world experience of anakinra for the treatment of immune effector cell-associated neurotoxicity syndrome in large B-cell lymphoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Real world experience of anakinra for the treatment of immune effector cell-associated neurotoxicity syndrome in large B-cell lymphoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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