What question did this study set out to answer?

To evaluate the impact of bridging therapy on the efficacy of CD19 CAR T cell therapy in diffuse large B cell lymphoma.

December 8, 2025BloodOpen Access

Impact of bridging therapy on efficacy of CD19 CAR T cell therapy in diffuse-large B cell lymphoma: Histology and the choice of drug matter

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Authors

VBViktoria BlumenbergHarvard University SSSabine SeiffertLeipzig University PNPhilipp NakovUniversity Hospital Schleswig-Holstein

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Implication

Retrospective analysis indicates bridging therapy affects CAR T cell therapy efficacy in diffuse large B cell lymphoma, implying choice of drugs matters.

Key Points

To evaluate the impact of bridging therapy on the efficacy of CD19 CAR T cell therapy in diffuse large B cell lymphoma.
Retrospective analysis of a multicenter cohort from 13 German hospitals.
Patients treated between January 2019 and May 2025 were included.
Bridging therapies assessed included various chemotherapy regimens and radiotherapy, with outcomes measured using Lugano criteria.
471 patients evaluated, showing significant differences in progression-free survival (PFS) based on bridging therapy choice.
Histologic subtype, lactate dehydrogenase, and extra nodal disease significantly influenced PFS.
Patients achieving complete response (CR) had higher PFS compared to partial remission (PR), stable disease (SD), and progressive disease (PD).

Cite This Study

Blumenberg et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5ac https://doi.org/10.1182/blood-2025-1949

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Implication

Retrospective analysis indicates bridging therapy affects CAR T cell therapy efficacy in diffuse large B cell lymphoma, implying choice of drugs matters.

Impact of bridging therapy on efficacy of CD19 CAR T cell therapy in diffuse-large B cell lymphoma: Histology and the choice of drug matter

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of bridging therapy on efficacy of CD19 CAR T cell therapy in diffuse-large B cell lymphoma: Histology and the choice of drug matter

Discussion

Member takes

Implication

Key Points

Cite This Study

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