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To categorize the EBV status and epigenetic state of lymphoma specimens in Ethiopia.

December 8, 2025BloodOpen Access

EBV status of lymphoma specimens from Ethiopia: Initial categorization of pathology and epigenetic state of EBV

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To categorize the EBV status and epigenetic state of lymphoma specimens in Ethiopia.
Conducted EBER-ISH technique for EBV detection in lymphoma samples.
Collected formalin-fixed paraffin-embedded tissues and blood samples from patients.
Analyzed viral epigenome methylation profile using multiplex PCR-mass-spectrometry assay.
288 participants diagnosed with lymphoma; 32% with Hodgkin lymphoma, 68% with non-Hodgkin lymphoma.
26.9% EBER positivity rate in analyzed samples, indicating association with EBV.
EBV detected in 25.4% of non-Hodgkin lymphoma samples and 42.9% of Hodgkin lymphoma samples.

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Research reveals significant EBV presence in lymphoma cases in Ethiopia, suggesting its role as a prognostic variable.

Haile et al. (2025) studied this question.

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