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This research investigates the role of cyclin D1 in transcriptional regulation and its implications in t(11;14) multiple myeloma.

December 8, 2025BloodOpen Access

Cyclin D1 beyond the cell cycle: A new role in t(11;14) multiple myeloma

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Reveals transcriptional regulation and immune response in multiple myeloma via cyclin D1, suggesting new treatment strategies.

This research investigates the role of cyclin D1 in transcriptional regulation and its implications in t(11;14) multiple myeloma.
Utilized RNA-seq from two independent primary multiple myeloma cohorts to analyze CCND1 expression.
Generated CCND1 knockout clones in t(11;14) MM using CRISPR/Cas9.
Performed ATAC-seq and ChIP-seq to analyze chromatin changes and histone marks in cell lines.
Identified 21 upregulated and 21 downregulated genes associated with CCND1 expression in multiple myeloma cases.
Observed changes in histone marks and chromatin accessibility related to CCND1 knockouts.
Highlighted a role for cyclin D1 in metabolic plasticity and survival under arginine depletion.

Shivaram et al. (2025) studied this question.

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