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December 8, 2025BloodOpen Access

Indole-related metabolites suppress the anti-tumor function of CD8+ T cells in the bone marrow microenvironment of multiple myeloma

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Authors

XJXiaoyun JinCapital Medical University

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Implication

Metabolomic profiling reveals indole-3-acetic acid and indole-3-propionic acid impair CD8+ T cells in multiple myeloma, highlighting a new mechanism of immune suppression.

Key Points

  • The research investigates the role of indole-related metabolites in suppressing the anti-tumor function of CD8+ T cells within the bone marrow of multiple myeloma patients.
  • Conducted metabolomic profiling of the bone marrow microenvironment from multiple myeloma patients.
  • Analyzed CD8+ T cell function and immune checkpoint expression using flow cytometry.
  • Evaluated the effects of indole derivatives on CAR T cell cytotoxicity in vitro.
  • Indole-3-acetic acid and indole-3-propionic acid significantly suppress CD8+ T cell activity in the bone marrow.
  • CD8+ T cells in multiple myeloma display an activated phenotype but impaired function with increased immune checkpoint expression.
  • Amino acid metabolism pathways are altered in multiple myeloma, contributing to immune evasion.

Cite This Study

Xiaoyun Jin (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5f8https://doi.org/10.1182/blood-2025-3933
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi-omics reveals immune features in immune and non-immune cells, an IFN-γ/IFN-α-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma2025
  2. 2Multi-omics reveals immune features in immune and non-immune cells, an IFN-γ/IFN-α-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma2025 · 1 citations
  3. 3Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma2025 · 2 citations
  4. 4Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma2025
  5. 5IL-6-driven metabolic reprogramming of the multiple myeloma microenvironment2026