Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Efficacy and safety of chimeric antigen receptor (CAR) T-cell therapy in richter transformation: A systematic review and meta-analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

KDKarna DesaiSGSandeep GuntukuASAnubhuti Sharma

Discussion

Loading...

Member takes

Overview

Systematic review reports CAR T-cell therapy's efficacy and safety in Richter transformation, indicating possible survival benefits.

Key Points

  • This research aimed to evaluate the efficacy and safety of CAR T-cell therapy in patients with Richter transformation.
  • Performed systematic search of PubMed, Embase, and Cochrane databases
  • Identified studies evaluating CAR T-cell therapy outcomes in Richter transformation
  • Analyzed overall response rate, complete response rate, progression-free survival, and overall survival
  • Pooled overall response rate was 68%
  • Complete response rate was 48.3%
  • At one year, progression-free survival was 43.7%
  • Overall survival at one year was 52.5%
  • Incidence of grade >3 cytokine release syndrome was 14.5%

Cite This Study

Desai et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d626https://doi.org/10.1182/blood-2025-7658
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anti-CD19 chimeric antigen receptor T-cell therapy has less efficacy in Richter transformation than in <i>de novo</i> large B-cell lymphoma and transformed low-grade B-cell lymphoma2024 · 4 citations
  2. 2Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy for Richter Transformation: An International, Multicenter, Retrospective Study2024 · 46 citations
  3. 3Multi-centre real-world outcome of patients with Richter transformation receiving CD19-directed commercial CAR T-cell therapy in Australia.2025
  4. 4CAR-T Cell Therapy Versus Salvage Chemotherapy in Relapsed/Refractory DLBCL: A Systematic Review and Meta-Analysis Integrating Radiologic, Laboratory, and Histopathologic Correlates.2026
  5. 5Immune exhaustion limits CD19 CAR-T efficacy in Richter's transformation2025