Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Immune exhaustion limits CD19 CAR-T efficacy in Richter's transformation

View Full Paper
Ask AI
Bookmark
Share

Authors

SHSean HaneyDMDouglas MarachionMHMohammad Hussaini

Discussion

Loading...

Member takes

Overview

Retrospective analysis reveals T cell exhaustion and tumor microenvironment influence CAR-T durability in Richter's transformation.

Key Points

  • Investigate the efficacy of CD19 CAR-T therapy in patients with Richter's transformation and the role of T cell exhaustion.
  • Retrospective analysis of 15 patients with RT-DLBCL treated with CD19 CAR-T and comparison with de novo DLBCL.
  • Assessment of peripheral blood mononuclear cells and RNA expression using NanoString profiling.
  • Evaluation of clinical outcomes and immune correlates post-CAR-T infusion.
  • 80% overall response rate at day 30; 47% at 3 months in RT patients.
  • Confirmed higher frequencies of exhausted T cells in RT compared to de novo DLBCL.
  • Increased expression of exhaustion markers ENTPD1 and DUSP2 in tumors from RT patients.

Cite This Study

Haney et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d279https://doi.org/10.1182/blood-2025-1791
View Full Paper
Ask AI
Bookmark
Share