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December 8, 2025BloodOpen Access

Comparison of haploidentical donors for pediatric patients undergoing hematopoietic stem cell transplantation: 10-year outcomes from a single-center experience

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Authors

LVLaura Villarreal‐Martínez

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Overview

Retrospective analysis compares graft-versus-host disease and survival in pediatric patients using sibling or parental donors.

Key Points

  • To compare overall survival and the incidence of acute and chronic graft-versus-host disease according to donor type in pediatric patients.
  • Retrospective study of 85 pediatric patients under 16 years
  • Compared outcomes between haploidentical transplants from parent vs sibling donors
  • Analyzed clinical characteristics, engraftment times, and rates of GVHD and non-relapse mortality.
  • Higher incidence of acute GVHD in parental donor transplants at 49.5% vs 15.2% for sibling donors
  • No cases of moderate or severe chronic GVHD observed in sibling donor transplants
  • Non-relapse mortality significantly higher in parental donor group at 20.0%

Cite This Study

Laura Villarreal‐Martínez (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d646https://doi.org/10.1182/blood-2025-7769
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