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December 8, 2025BloodOpen Access

Older age and complex karyotype are the main predictors of mortality irrespective of allogeneic transplant in therapy-related myeloid neoplasms: A single‑center retrospective cohort

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JMJ Mantovani

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Overview

Retrospective cohort shows older age and complex karyotype predict mortality in therapy-related leukemia, highlighting transplant implications.

Key Points

  • This research aims to identify predictors of mortality in therapy-related myeloid neoplasms in patients undergoing allogeneic transplant.
  • Retrospective evaluation of 86 patients diagnosed with t-MDS and t-AML.
  • Analysis of overall survival and cumulative incidence of t-MDS/t-AML related mortality.
  • Utilization of Fine and Gray models to identify predictors of mortality.
  • Median overall survival was 35.1%, significantly differing between patients undergoing alloSCT and those who did not.
  • Older age and complex karyotype emerged as strong independent predictors of mortality.
  • Cumulative incidence of t-AML/t-MDS-related mortality was 63% at 2 years.

Cite This Study

J Mantovani (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d672https://doi.org/10.1182/blood-2025-5161
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