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December 8, 2025Blood

Peripheral immune checkpoints predict prognosis and reveal PD-1/treg/IL-10 crosstalk in B cell lymphoma

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Authors

SLSijia LiRZRuixin Zheng

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Overview

Observational analysis identifies immune checkpoints as biomarkers of prognosis in B-cell lymphoma, suggesting immune evasion roles.

Key Points

  • This research investigates the prognostic significance of immune checkpoints in B-cell lymphoma.
  • Retrospective analysis of 140 B-cell lymphoma patients
  • Measured immune checkpoint expression on CD4+/CD8+ T cells via flow cytometry
  • Correlated immune checkpoint expression with Treg proportions and IL-10 levels
  • Aggressive B-cell lymphoma exhibited higher immune checkpoint expression than indolent subtypes
  • PD-1 expression on CD4+ T cells was significantly higher in relapsed patients compared to those in complete remission
  • Treg proportions and IL-10 levels were also significantly elevated in relapsed patients compared to complete remission

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d69chttps://doi.org/10.1182/blood-2025-7088
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune dysregulation in newly diagnosed DLBCL: From clinical observations to molecular mechanisms2025
  2. 2A dual compartment peripheral blood signature of soluble and membrane-bound immune checkpoints predicts outcome in lymphoma patients2025
  3. 3Immunological profiling for short-term predictive analysis in PD-1/PD-L1 therapy for lung cancer2024 · 5 citations
  4. 4Exploring the Dynamics of B Cell Subpopulations in Response to Immune Checkpoint Inhibitors: A Prospective Study2024
  5. 5Abstract 5374: Immune checkpoint protein expression of PD-1 shows prognostic significance in large B-cell lymphomas of the central nervous system.2026