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December 8, 2025BloodOpen Access

Multistep molecular trajectory during monocytic myeloid-derived suppressor cell induction by diffuse large B-cell lymphoma cells

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Authors

YSYuji ShimuraKyoto Prefectural UniversityTNTakahisa NakamuraKyoto Prefectural University of MedicineSMShinsuke MizutaniKyoto Prefectural University

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Overview

Indirect co-culture reveals how DLBCL cells induce myeloid-derived suppressor cells, highlighting roles of cytokines in treatment resistance.

Key Points

  • This research addresses how diffuse large B-cell lymphoma cells induce monocytic myeloid-derived suppressor cells from normal peripheral blood mononuclear cells.
  • Used human diffuse large B-cell lymphoma cell lines and peripheral blood mononuclear cells for indirect co-culture
  • Assessed myeloid-derived suppressor cell induction via flow cytometry
  • Analyzed gene expression with microarray analysis and cytokine arrays
  • All four DLBCL cell lines effectively induced CD14+/HLA-DR-/low myeloid cells
  • MIF and IL-10 were crucial cytokines in the induction process
  • Gene expression analysis showed dynamic inflammatory response and TNF-α signaling that changed over time

Cite This Study

Shimura et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6a0https://doi.org/10.1182/blood-2025-7091
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Also Consider

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  1. 1Celmods potently inhibit m-MDSC induction by targeting IL-10 and MIF in multiple myeloma2025
  2. 2Cutaneous diffuse large B-cell lymphoma induce a macrophage immunosuppressive phenotype through IL-10 secretion2025
  3. 3Cellular and molecular impacts of CELMoDs and IMiD on the induction of myeloid‐derived suppressor cells by myeloma cells2026
  4. 410.03 Long lasting alterations of the immunophenotype and cytokine signature of DLBCL survivors results in persisting immune dysfunction2024 · 1 citations
  5. 5AML blasts and monocytic myeloid-derived suppressor cells (M-MDSC) inhibit human mucosal-associated invariant t (MAIT) cells activation.2025